Human cervicovaginal mucus contains an activity that hinders HIV-1 movement.
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ABSTRACT:
SUBMITTER: Shukair SA
PROVIDER: S-EPMC3732193 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Human cervicovaginal mucus contains an activity that hinders HIV-1 movement.
Shukair S A SA Allen S A SA Cianci G C GC Stieh D J DJ Anderson M R MR Baig S M SM Gioia C J CJ Spongberg E J EJ Kauffman S M SM McRaven M D MD Lakougna H Y HY Hammond C C Kiser P F PF Hope T J TJ
Mucosal immunology 20120919 2
Cervical and vaginal epithelia are primary barriers against HIV type I (HIV-1) entry during male-to-female transmission. Cervical mucus (CM) is produced by the endocervix and forms a layer locally as well as in the vaginal compartment in the form of cervicovaginal mucus (CVM). To study the potential barrier function of each mucus type during HIV-1 transmission, we quantified HIV-1 mobility in CM and CVM ex vivo using fluorescent microscopy. Virions and 200-nm PEGylated beads were digitally track ...[more]
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