RemA is a DNA-binding protein that activates biofilm matrix gene expression in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Winkelman JT
PROVIDER: S-EPMC3732408 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
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RemA is a DNA-binding protein that activates biofilm matrix gene expression in Bacillus subtilis.
Winkelman Jared T JT Bree Anna C AC Bate Ashley R AR Eichenberger Patrick P Gourse Richard L RL Kearns Daniel B DB
Molecular microbiology 20130507 5
Biofilm formation in Bacillus subtilis requires expression of the eps and tapA-sipW-tasA operons to synthesize the extracellular matrix components, extracellular polysaccharide and TasA amyloid proteins, respectively. Expression of both operons is inhibited by the DNA-binding protein master regulator of biofilm formation SinR and activated by the protein RemA. Here we show that RemA is a DNA-binding protein that binds to multiple sites upstream of the promoters of both operons and is both necess ...[more]
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2019-03-27 | GSE128875 | GEO