Ontology highlight
ABSTRACT:
SUBMITTER: Cao W
PROVIDER: S-EPMC3732485 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Cao Weiping W Manicassamy Santhakumar S Tang Hua H Kasturi Sudhir Pai SP Pirani Ali A Murthy Niren N Pulendran Bali B
Nature immunology 20080831 10
Robust production of type I interferon (IFN-alpha/beta) in plasmacytoid dendritic cells (pDCs) is crucial for antiviral immunity. Here we show involvement of the mammalian target of rapamycin (mTOR) pathway in regulating interferon production by pDCs. Inhibition of mTOR or its 'downstream' mediators, the p70 ribosomal S6 protein kinases p70S6K1 and p70S6K2, during pDC activation by Toll-like receptor 9 (TLR9) blocked the interaction of TLR9 with the adaptor MyD88 and subsequent activation of the ...[more]