Resolution phase lipid mediators of inflammation: agonists of resolution.
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ABSTRACT:
SUBMITTER: Serhan CN
PROVIDER: S-EPMC3732499 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Resolution phase lipid mediators of inflammation: agonists of resolution.
Serhan Charles N CN Chiang Nan N
Current opinion in pharmacology 20130606 4
Lipid mediators are appreciated for their roles in leukocyte traffic required in host defense. With identification of novel resolution phase mediators, resolvins, protectins and maresins, these three families and their aspirin-triggered forms, given their potent stereoselective actions with human cells and animal disease models, are coined specialized pro-resolving mediators (SPM). Stereochemistries of key SPM are established and several groups reported organic synthesis. Given increased availab ...[more]
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