Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC3732831 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Li Zhizhong Z Zhang Yunyu Y Ramanujan Krishnan K Ma Yan Y Kirsch David G DG Glass David J DJ
Cancer research 20130327 10
Embryonic rhabdomyosarcoma (ERMS) is the most common soft-tissue tumor in children. Here, we report the identification of the minor groove DNA-binding factor high mobility group AT-hook 2 (HMGA2) as a driver of ERMS development. HMGA2 was highly expressed in normal myoblasts and ERMS cells, where its expression was essential to maintain cell proliferation, survival in vitro, and tumor outgrowth in vivo. Mechanistic investigations revealed that upregulation of the insulin-like growth factor (IGF) ...[more]