Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians.
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ABSTRACT:
SUBMITTER: Ngu JH
PROVIDER: S-EPMC3733077 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians.
Ngu Jing H JH Wallace Mary C MC Merriman Tony R TR Gearry Richard B RB Stedman Catherine Am CA Roberts Rebecca L RL
SpringerPlus 20130730
<h4>Purpose</h4>The precise etiology of autoimmune hepatitis (AIH) remains unknown, although a number of genetic loci have been implicated in the susceptibility of type 1 AIH. The purpose of this study was to test for association of these loci with type 1 AIH in New Zealand Caucasians.<h4>Methods</h4>77 AIH patients and 485 healthy controls were genotyped for the SNPs rs2187668 (HLA-DRB*03:01), rs660895 (HLA-DRB*04:01), rs3749971 (HLA-A1-B8-DR3), rs231775 (CLTLA4), rs1800629 (TNF), and rs1800682 ...[more]
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