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The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.

ABSTRACT: Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.

SUBMITTER: Aweda TA

PROVIDER: S-EPMC3733397 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.

Aweda Tolulope A TA Ikotun Oluwatayo O Mastren Tara T Cannon Carolyn L CL Wright Brian B Youngs Wiley J WJ Cutler Cathy C Guthrie James J Lapi Suzanne E SE

MedChemComm 20130601 6

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies. ...[more]

PMID: 23930200

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