Ontology highlight
ABSTRACT:
SUBMITTER: Stallings-Mann ML
PROVIDER: S-EPMC3733503 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Science translational medicine 20120701 142
Lung cancer is more deadly than colon, breast, and prostate cancers combined, and treatment improvements have failed to improve prognosis significantly. Here, we identify a critical mediator of lung cancer progression, Rac1b, a tumor-associated protein with cell-transforming properties that are linked to the matrix metalloproteinase (MMP)-induced epithelial-mesenchymal transition (EMT) in lung epithelial cells. We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice st ...[more]