Ontology highlight
ABSTRACT:
SUBMITTER: Kalams SA
PROVIDER: S-EPMC3733506 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Kalams Spyros A SA Parker Scott D SD Elizaga Marnie M Metch Barbara B Edupuganti Srilatha S Hural John J De Rosa Stephen S Carter Donald K DK Rybczyk Kyle K Frank Ian I Fuchs Jonathan J Koblin Beryl B Kim Denny H DH Joseph Patrice P Keefer Michael C MC Baden Lindsey R LR Eldridge John J Boyer Jean J Sherwat Adam A Cardinali Massimo M Allen Mary M Pensiero Michael M Butler Chris C Khan Amir S AS Yan Jian J Sardesai Niranjan Y NY Kublin James G JG Weiner David B DB
The Journal of infectious diseases 20130708 5
<h4>Background</h4>DNA vaccines have been very poorly immunogenic in humans but have been an effective priming modality in prime-boost regimens. Methods to increase the immunogenicity of DNA vaccines are needed.<h4>Methods</h4>HIV Vaccine Trials Network (HVTN) studies 070 and 080 were multicenter, randomized, clinical trials. The human immunodeficiency virus type 1 (HIV-1) PENNVAX®-B DNA vaccine (PV) is a mixture of 3 expression plasmids encoding HIV-1 Clade B Env, Gag, and Pol. The interleukin ...[more]