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The core-inversible micelles for hydrophilic drug delivery.

ABSTRACT: A unique core-inversible micelle (CIM) was formed via PEG(5k)CA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line.

SUBMITTER: Huang W 

PROVIDER: S-EPMC3733992 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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The core-inversible micelles for hydrophilic drug delivery.

Huang Wenzhe W   Shi Changying C   Shao Yu Y   Lam Kit S KS   Luo Juntao J  

Chemical communications (Cambridge, England) 20130701 59

A unique core-inversible micelle (CIM) was formed via PEG(5k)CA8 for hydrophilic drug delivery. An amyloid-fibril-inhibiting water-soluble molecule, congo red (CR), has been loaded into the hydrophilic core of CIMs. The targeting folate-CIMs significantly enhanced the intracellular delivery of hydrophilic CR in a folate receptor-expressing cell line. ...[more]

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