Dataset Information

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project.

ABSTRACT:

Background

Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe.

Objectives

We estimated the short-term effects of PM with aerodynamic diameter ? 10 ?m (PM10), ? 2.5 ?m (PM2.5), and between 2.5 and 10 ?m (PM2.5-10) on all-cause, cardiovascular, and respiratory mortality in 10 European Mediterranean metropolitan areas within the MED-PARTICLES project.

Methods

We analyzed data from each city using Poisson regression models, and combined city-specific estimates to derive overall effect estimates. We evaluated the sensitivity of our estimates to co-pollutant exposures and city-specific model choice, and investigated effect modification by age, sex, and season. We applied distributed lag and threshold models to investigate temporal patterns of associations.

Results

A 10-?g/m3 increase in PM2.5 was associated with a 0.55% (95% CI: 0.27, 0.84%) increase in all-cause mortality (0-1 day cumulative lag), and a 1.91% increase (95% CI: 0.71, 3.12%) in respiratory mortality (0-5 day lag). In general, associations were stronger for cardiovascular and respiratory mortality than all-cause mortality, during warm versus cold months, and among those ? 75 versus < 75 years of age. Associations with PM2.5-10 were positive but not statistically significant in most analyses, whereas associations with PM10 seemed to be driven by PM2.5.

Conclusions

We found evidence of adverse effects of PM2.5 on mortality outcomes in the European Mediterranean region. Associations with PM2.5-10 were positive but smaller in magnitude. Associations were stronger for respiratory mortality when cumulative exposures were lagged over 0-5 days, and were modified by season and age.

SUBMITTER: Samoli E

PROVIDER: S-EPMC3734494 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project.

Samoli Evangelia E Stafoggia Massimo M Rodopoulou Sophia S Ostro Bart B Declercq Christophe C Alessandrini Ester E Díaz Julio J Karanasiou Angeliki A Kelessis Apostolos G AG Le Tertre Alain A Pandolfi Paolo P Randi Giorgia G Scarinzi Cecilia C Zauli-Sajani Stefano S Katsouyanni Klea K Forastiere Francesco F

Environmental health perspectives 20130517 8

<h4>Background</h4>Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe.<h4>Objectives</h4>We estimated the short-term effects of PM with aerodynamic diameter ≤ 10 μm (PM10), ≤ 2.5 μm (PM2.5), and between 2.5 and 10 μm (PM2.5-10) on all-cause, cardiovascular, and respiratory mortality in 10 European Mediterranean metropolitan areas within the MED-PARTICLES project.<h4>Methods</h4>We analyze ...[more]

PMID: 23687008

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Project description:BACKGROUND:Coarse particulate matter with aerodynamic diameter between 2.5 and [Formula: see text] ([Formula: see text]) air pollution is a severe environmental problem in developing countries, but its challenges to public health were rarely evaluated. OBJECTIVE:We aimed to investigate the associations between day-to-day changes in [Formula: see text] and cause-specific mortality in China. METHODS:We conducted a nationwide daily time-series analysis in 272 main Chinese cities from 2013 to 2015. The associations between [Formula: see text] concentrations and mortality were analyzed in each city using overdispersed generalized additive models. Two-stage Bayesian hierarchical models were used to estimate national and regional average associations, and random-effect models were used to pool city-specific concentration-response curves. Two-pollutant models were adjusted for fine particles with aerodynamic diameter [Formula: see text] ([Formula: see text]) or gaseous pollutants. RESULTS:Overall, we observed positive and approximately linear concentration-response associations between [Formula: see text] and daily mortality. A [Formula: see text] increase in [Formula: see text] was associated with higher mortality due to nonaccidental causes [0.23%; 95% posterior interval (PI): 0.13, 0.33], cardiovascular diseases (CVDs; 0.25%; 95% PI: 0.13, 0.37), coronary heart disease (CHD; 0.21%; 95% PI: 0.05, 0.36), stroke (0.21%; 95% PI: 0.08, 0.35), respiratory diseases (0.26%; 95% PI: 0.07, 0.46), and chronic obstructive pulmonary disease (COPD; 0.34%; 95% PI: 0.12, 0.57). Associations were stronger for cities in southern vs. northern China, with significant differences for total and cardiovascular mortality. Associations with [Formula: see text] were of similar magnitude to those for [Formula: see text] in both single- and two-pollutant models with mutual adjustment. Associations were robust to adjustment for gaseous pollutants other than nitrogen dioxide and sulfur dioxide. Meta-regression indicated that a larger positive correlation between [Formula: see text] and [Formula: see text] predicted stronger city-specific associations between [Formula: see text] and total mortality. CONCLUSIONS:This analysis showed significant associations between short-term [Formula: see text] exposure and daily nonaccidental and cardiopulmonary mortality based on data from 272 cities located throughout China. Associations appeared to be independent of exposure to [Formula: see text], carbon monoxide, and ozone. https://doi.org/10.1289/EHP2711.

Project description:Identifying the sources, composition, and temporal variability of fine (PM2.5) and coarse (PM2.5-10) particles is a crucial component in understanding particulate matter (PM) toxicity and establishing proper PM regulations. In this study, a Harvard Impactor was used to collect daily integrated fine and coarse particle samples every third day for 9 years at a single site in Boston, MA. In total, 1,960 filters were analyzed for elements, black carbon (BC), and total PM mass. Positive Matrix Factorization (PMF) was used to identify source types and quantify their contributions to ambient PM2.5 and PM2.5-10. BC and 17 elements were identified as the main constituents in our samples. Results showed that BC, S, and Pb were associated exclusively with the fine particle mode, while 84% of V and 79% of Ni were associated with this mode. Elements mostly found in the coarse mode, over 80%, included Ca, Mn (road dust), and Cl (sea salt). PMF identified six source types for PM2.5 and three source types for PM2.5-10. Source types for PM2.5 included regional pollution, motor vehicles, sea salt, crustal/road dust, oil combustion, and wood burning. Regional pollution contributed the most, accounting for 48% of total PM2.5 mass, followed by motor vehicles (21%) and wood burning (19%). Source types for PM2.5-10 included crustal/road dust (62%), motor vehicles (22%), and sea salt (16%). A linear decrease in PM concentrations with time was observed for both fine (-5.2%/yr) and coarse (-3.6%/yr) particles. The fine-mode trend was mostly related to oil combustion and regional pollution contributions. Average PM2.5 concentrations peaked in summer (10.4 µg/m3), while PM2.5-10 concentrations were lower and demonstrated little seasonal variability. The findings of this study show that PM2.5 is decreasing more sharply than PM2.5-10 over time. This suggests the increasing importance of PM2.5-10 and traffic-related sources for PM exposure and future policies.Although many studies have examined fine and coarse particle composition and sources, few studies have used concurrent measurements of these two fractions. Our analysis suggests that fine and coarse particles exhibit distinct compositions and sources. With better knowledge of the compositional and source differences between these two PM fractions, better decisions can be made about PM regulations. Further, such information is valuable in enabling epidemiologists to understand the ensuing health implications of PM exposure.

Dataset Information

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project.

Background

Objectives

Methods

Results

Conclusions

Publications

Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project.

Similar Datasets

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