Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.
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ABSTRACT:
SUBMITTER: Gnad F
PROVIDER: S-EPMC3734570 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.
Gnad Florian F Young Amy A Zhou Wei W Lyle Karen K Ong Christy C CC Stokes Matthew P MP Silva Jeffrey C JC Belvin Marcia M Friedman Lori S LS Koeppen Hartmut H Minden Audrey A Hoeflich Klaus P KP
Molecular & cellular proteomics : MCP 20130422 8
Although K-Ras, Cdc42, and PAK4 signaling are commonly deregulated in cancer, only a few studies have sought to comprehensively examine the spectrum of phosphorylation-mediated signaling downstream of each of these key signaling nodes. In this study, we completed a label-free quantitative analysis of oncogenic K-Ras, activated Cdc42, and PAK4-mediated phosphorylation signaling, and report relative quantitation of 2152 phosphorylated peptides on 1062 proteins. We define the overlap in phosphopept ...[more]
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