Ontology highlight
ABSTRACT:
SUBMITTER: Mills KR
PROVIDER: S-EPMC373480 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Mills Kenna R KR Reginato Mauricio M Debnath Jayanta J Queenan Bridget B Brugge Joan S JS
Proceedings of the National Academy of Sciences of the United States of America 20040301 10
The molecular events regulating the elimination of cells to create a hollow lumen during tissue development are poorly understood. By using an in vitro morphogenesis model in which MCF-10A human mammary epithelial cells form hollow acini-like structures, we have observed both caspase-mediated apoptosis and autophagy associated with cells that are lost during lumen formation. Here, we show that the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediates induction of autophagic pr ...[more]