Genetic predispositions to childhood leukemia.
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ABSTRACT:
SUBMITTER: Stieglitz E
PROVIDER: S-EPMC3734905 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic predispositions to childhood leukemia.
Stieglitz Elliot E Loh Mignon L ML
Therapeutic advances in hematology 20130801 4
While the majority of leukemia cases occur in the absence of any known predisposing factor, there are germline mutations that significantly increase the risk of developing hematopoietic malignancies in childhood. In this review article, we describe a number of these mutations and their clinical features. These predispositions can be broadly classified as those leading to bone marrow failure, those involving tumor suppressor genes, DNA repair defects, immunodeficiencies or other congenital syndro ...[more]
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