Ontology highlight
ABSTRACT:
SUBMITTER: Tarning J
PROVIDER: S-EPMC3736305 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Tarning J J Zongo I I Somé F A FA Rouamba N N Parikh S S Rosenthal P J PJ Hanpithakpong W W Jongrak N N Day N P J NP White N J NJ Nosten F F Ouedraogo J-B JB Lindegardh N N
Clinical pharmacology and therapeutics 20120118 3
Dihydroartemisinin-piperaquine is being increasingly used as a first-line artemisinin combination treatment for malaria. The aim of this study was to describe the pharmacokinetic and pharmacodynamic properties of piperaquine in 236 children with uncomplicated falciparum malaria in Burkina Faso. They received a standard body weight-based oral 3-day fixed-dose dihydroartemisinin-piperaquine regimen. Capillary plasma concentration-time profiles were characterized using nonlinear mixed-effects model ...[more]