Ontology highlight
ABSTRACT:
SUBMITTER: Birk AV
PROVIDER: S-EPMC3736700 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Birk Alexander V AV Liu Shaoyi S Soong Yi Y Mills William W Singh Pradeep P Warren J David JD Seshan Surya V SV Pardee Joel D JD Szeto Hazel H HH
Journal of the American Society of Nephrology : JASN 20130711 8
Ischemia causes AKI as a result of ATP depletion, and rapid recovery of ATP on reperfusion is important to minimize tissue damage. ATP recovery is often delayed, however, because ischemia destroys the mitochondrial cristae membranes required for mitochondrial ATP synthesis. The mitochondria-targeted compound SS-31 accelerates ATP recovery after ischemia and reduces AKI, but its mechanism of action remains unclear. Here, we used a polarity-sensitive fluorescent analog of SS-31 to demonstrate that ...[more]