Unknown

Dataset Information

0

Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.

ABSTRACT: Signaling between cells in the anterior (A) and posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. Here we extend investigations of the processes downstream of en by using expression array analysis to compare A and P cells. A total of 102 candidate genes were identified that express differentially in the A and P compartments; four were characterized: Stubble (Sb) expression is restricted to A cells due to repression by en. CG15905, CG16884; CG10200/hase und igel (hui) are expressed in A cells downstream of Hh signaling; and RNA interference for hui, Stubble, and CG16884 revealed that each is essential to wing development.

SUBMITTER: Ibrahim DM 

PROVIDER: S-EPMC3737175 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.

Ibrahim Daniel M DM   Biehs Brian B   Kornberg Thomas B TB   Klebes Ansgar A  

G3 (Bethesda, Md.) 20130807 8

Signaling between cells in the anterior (A) and posterior (P) compartments directs Drosophila wing disc development and is dependent on expression of the homeodomain transcription factor Engrailed (En) in P cells. Downstream of en, posteriorly expressed Hedgehog (Hh) protein signals across the A/P border to establish a developmental organizer that directs pattern formation and growth throughout the wing primordium. Here we extend investigations of the processes downstream of en by using expressi  ...[more]

Similar Datasets

Transcriptomics Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells
2013-05-04 | GSE46601 | GEO
Transcriptomics Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells
2013-05-04 | E-GEOD-46601 | biostudies-arrayexpress
Unknown Spatial regulation of expanded transcription in the Drosophila wing imaginal disc.
| S-EPMC6067730 | biostudies-literature
Unknown Membrane potential regulates Hedgehog signalling in the Drosophila wing imaginal disc.
| S-EPMC8024891 | biostudies-literature
Unknown Analysis of the Function of Apoptosis during Imaginal Wing Disc Regeneration in Drosophila melanogaster.
| S-EPMC5125585 | biostudies-literature
Transcriptomics Wing imaginal disc spatial expression
2003-01-08 | GSE93 | GEO
Unknown Essential roles for stat92E in expanding and patterning the proximodistal axis of the Drosophila wing imaginal disc.
| S-EPMC3776456 | biostudies-literature
Unknown Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
| S-EPMC3201923 | biostudies-literature
Unknown Hedgehog produced by the <i>Drosophila</i> wing imaginal disc induces distinct responses in three target tissues.
| S-EPMC7687861 | biostudies-literature
Unknown TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc.
| S-EPMC10499800 | biostudies-literature