Ontology highlight
ABSTRACT:
SUBMITTER: Banon-Rodriguez I
PROVIDER: S-EPMC3737202 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Banon-Rodriguez Inmaculada I Saez de Guinoa Julia J Bernardini Alejandra A Ragazzini Chiara C Fernandez Estefania E Carrasco Yolanda R YR Jones Gareth E GE Wandosell Francisco F Anton Ines Maria IM
PloS one 20130807 8
The spatial distribution of signals downstream from receptor tyrosine kinases (RTKs) or G-protein coupled receptors (GPCR) regulates fundamental cellular processes that control cell migration and growth. Both pathways rely significantly on actin cytoskeleton reorganization mediated by nucleation-promoting factors such as the WASP-(Wiskott-Aldrich Syndrome Protein) family. WIP (WASP Interacting Protein) is essential for the formation of a class of polarised actin microdomain, namely dorsal ruffle ...[more]