Ontology highlight
ABSTRACT:
SUBMITTER: Der BS
PROVIDER: S-EPMC3737258 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Der Bryan S BS Kuhlman Brian B
Current opinion in structural biology 20130531 4
There has been significant recent progress in the computational design of protein interactions including the creation of novel heterodimers, homodimers, nanohedra, fibril caps and a protein crystal. Essential to these successes has been the use of innovative strategies for finding binding modes that are achievable, that is, identifying binding partners and docked conformations that can be successfully stabilized via sequence optimization and backbone refinement. In many cases this has involved t ...[more]