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Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials.


ABSTRACT: The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.

SUBMITTER: Franquesa M 

PROVIDER: S-EPMC3737392 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: lessons learned from first clinical trials.

Franquesa Marcella M   Franquesa Marcella M   Hoogduijn Martin J MJ   Reinders Marlies E ME   Eggenhofer Elke E   Engela Anja U AU   Mensah Fane K FK   Torras Joan J   Pileggi Antonello A   van Kooten Cees C   Mahon Bernard B   Detry Oliver O   Popp Felix C FC   Benseler Volker V   Casiraghi Federica F   Johnson Christian C   Ancans Janis J   Fillenberg Barbara B   delaRosa Olga O   Aran Josep M JM   Roemeling-van Rhijn Marieke M   Pinxteren Jef J   Perico Norberto N   Gotti Eliana E   Christ Bruno B   Reading James J   Introna Martino M   Deans Robert R   Shagidulin Murat M   Farré Ramon R   Rambaldi Alessandro A   Sanchez-Fueyo Albert A   Obermajer Natasha N   Pulin Andrey A   Dor Frank J M F FJ   Portero-Sanchez Isabel I   Baan Carla C CC   Rabelink Ton J TJ   Remuzzi Giuseppe G   Betjes Michiel G H MG   Dahlke Marc H MH   Grinyó Josep M JM  

Transplantation 20130801 3


The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immun  ...[more]

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