Ontology highlight
ABSTRACT:
SUBMITTER: Cao H
PROVIDER: S-EPMC3737717 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cao Huojun H Jheon Andrew A Li Xiao X Sun Zhao Z Wang Jianbo J Florez Sergio S Zhang Zichao Z McManus Michael T MT Klein Ophir D OD Amendt Brad A BA
Development (Cambridge, England) 20130717 16
The mouse incisor is a remarkable tooth that grows throughout the animal's lifetime. This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of microRNAs in this process. Here, we describe the role of a novel Pitx2:miR-200c/141:noggin regulatory pathway in dental epithelial cell differentiation. miR-200c repressed noggin, an antagonist of Bmp signaling. Pitx2 expression caused an upregulation of ...[more]