Ontology highlight
ABSTRACT:
SUBMITTER: Clute SC
PROVIDER: S-EPMC3738202 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Clute Shalyn C SC Naumov Yuri N YN Watkin Levi B LB Aslan Nuray N Sullivan John L JL Thorley-Lawson David A DA Luzuriaga Katherine K Welsh Raymond M RM Puzone Roberto R Celada Franco F Selin Liisa K LK
Journal of immunology (Baltimore, Md. : 1950) 20101103 11
Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a process known as heterologous immunity. Because a challenge virus epitope may react with only a subset of the T cell repertoire in a cross-reactive epitope-specific memory pool, the vigorous cross-reactive response may be narrowly focused, or oligoclonal. We show in this article, by examining human T cell cross-reactivity between the HLA-A2-res ...[more]