Ontology highlight
ABSTRACT:
SUBMITTER: Manske M
PROVIDER: S-EPMC3738909 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Manske Magnus M Miotto Olivo O Campino Susana S Auburn Sarah S Almagro-Garcia Jacob J Maslen Gareth G O'Brien Jack J Djimde Abdoulaye A Doumbo Ogobara O Zongo Issaka I Ouedraogo Jean-Bosco JB Michon Pascal P Mueller Ivo I Siba Peter P Nzila Alexis A Borrmann Steffen S Kiara Steven M SM Marsh Kevin K Jiang Hongying H Su Xin-Zhuan XZ Amaratunga Chanaki C Fairhurst Rick R Socheat Duong D Nosten Francois F Imwong Mallika M White Nicholas J NJ Sanders Mandy M Anastasi Elisa E Alcock Dan D Drury Eleanor E Oyola Samuel S Quail Michael A MA Turner Daniel J DJ Ruano-Rubio Valentin V Jyothi Dushyanth D Amenga-Etego Lucas L Hubbart Christina C Jeffreys Anna A Rowlands Kate K Sutherland Colin C Roper Cally C Mangano Valentina V Modiano David D Tan John C JC Ferdig Michael T MT Amambua-Ngwa Alfred A Conway David J DJ Takala-Harrison Shannon S Plowe Christopher V CV Rayner Julian C JC Rockett Kirk A KA Clark Taane G TG Newbold Chris I CI Berriman Matthew M MacInnis Bronwyn B Kwiatkowski Dominic P DP
Nature 20120701 7407
Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality contro ...[more]