Ontology highlight
ABSTRACT:
SUBMITTER: Daigle SR
PROVIDER: S-EPMC3739029 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Daigle Scott R SR Olhava Edward J EJ Therkelsen Carly A CA Basavapathruni Aravind A Jin Lei L Boriack-Sjodin P Ann PA Allain Christina J CJ Klaus Christine R CR Raimondi Alejandra A Scott Margaret Porter MP Waters Nigel J NJ Chesworth Richard R Moyer Mikel P MP Copeland Robert A RA Richon Victoria M VM Pollock Roy M RM
Blood 20130625 6
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a pressing need for new therapies for this disease. Genetic and small molecule inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the development and maintenance of MLL-rearranged leukemia in model systems. Here we describe the characterization of EPZ-5676, a potent and selectiv ...[more]