Ontology highlight
ABSTRACT:
SUBMITTER: Wu X
PROVIDER: S-EPMC3739291 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Virology 20080918 2
To better understand the limits of antigenic reactivity and epitope accessibility of the V3 domain of primary HIV-1 isolates, we evaluated three human anti-V3 monoclonal antibodies (mAbs) and selected guinea pig vaccine sera for neutralization against reference panels of subtype B and C pseudoviruses derived from early stage infections. The mAbs and vaccine sera potently neutralized several prototype viruses, but displayed substantially less neutralization of most reference strains. In the prese ...[more]