Ontology highlight
ABSTRACT:
SUBMITTER: Apovian CM
PROVIDER: S-EPMC3739931 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Apovian Caroline M CM Aronne Louis L Rubino Domenica D Still Christopher C Wyatt Holly H Burns Colleen C Kim Dennis D Dunayevich Eduardo E
Obesity (Silver Spring, Md.) 20130501 5
<h4>Objective</h4>To examine the effects of naltrexone/bupropion (NB) combination therapy on weight and weight-related risk factors in overweight and obese participants.<h4>Design and methods</h4>CONTRAVE Obesity Research-II (COR-II) was a double-blind, placebo-controlled study of 1,496 obese (BMI 30-45 kg/m(2) ) or overweight (27-45 kg/m(2) with dyslipidemia and/or hypertension) participants randomized 2:1 to combined naltrexone sustained-release (SR) (32 mg/day) plus bupropion SR (360 mg/day) ...[more]