Ontology highlight
ABSTRACT:
SUBMITTER: Barzel B
PROVIDER: S-EPMC3740009 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Barzel Baruch B Barabási Albert-László AL
Nature biotechnology 20130714 8
Predictions of physical and functional links between cellular components are often based on correlations between experimental measurements, such as gene expression. However, correlations are affected by both direct and indirect paths, confounding our ability to identify true pairwise interactions. Here we exploit the fundamental properties of dynamical correlations in networks to develop a method to silence indirect effects. The method receives as input the observed correlations between node pai ...[more]