Ontology highlight
ABSTRACT:
SUBMITTER: Koveal D
PROVIDER: S-EPMC3740349 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Koveal Dorothy D Schuh-Nuhfer Natasha N Ritt Daniel D Page Rebecca R Morrison Deborah K DK Peti Wolfgang W
Science signaling 20121218 255
Kinase suppressor of Ras-1 (KSR-1) is an essential scaffolding protein that coordinates the assembly of the mitogen-activated protein kinase (MAPK) module, consisting of the MAPK kinase kinase Raf, the MAPK kinase MEK (mitogen-activated or extracellular signal-regulated protein kinase kinase), and the MAPK ERK (extracellular signal-regulated kinase) to facilitate activation of MEK and thus ERK. Although KSR-1 is targeted to the cell membrane in part by its atypical C1 domain, which binds to phos ...[more]