Ontology highlight
ABSTRACT:
SUBMITTER: Johansson H
PROVIDER: S-EPMC3740522 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Johansson Henrik H Cailly Thomas T Rojas Bie Thomsen Alex A Bräuner-Osborne Hans H Sejer Pedersen Daniel D
Beilstein journal of organic chemistry 20130709
(R)-3 (NPS 2143) is a negative allosteric modulator of the human calcium-sensing receptor (CaSR) and as such represents an important pharmacological tool compound for studying the CaSR. Herein, we disclose for the first time a complete experimental description, detailed characterisation and assessment of enantiomeric purity for (R)-3. An efficient, reproducible and scalable synthesis of (R)-3 that requires a minimum of chromatographic purification steps is presented. (R)-3 was obtained in excell ...[more]