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Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition.

ABSTRACT: Katsumadain A, a naturally occurring in?uenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3740603 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Bioinspired total synthesis of katsumadain A by organocatalytic enantioselective 1,4-conjugate addition.

Wang Yongguang Y Bao Ruiyang R Huang Shengdian S Tang Yefeng Y

Beilstein journal of organic chemistry 20130806

Katsumadain A, a naturally occurring inﬂuenza virus neuraminidase (NA) inhibitor, was synthesized by using a bioinspired, organocatalytic enantioselective 1,4-conjugate addition of styryl-2-pyranone with cinnamaldehyde, followed by a tandem Horner-Wadsworth-Emmons/oxa Michael addition. ...[more]

PMID: 23946860

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