Candidate gene linkage approach to identify DNA variants that predispose to preterm birth.
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ABSTRACT:
SUBMITTER: Bream EN
PROVIDER: S-EPMC3740714 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Candidate gene linkage approach to identify DNA variants that predispose to preterm birth.
Bream Elise N A EN Leppellere Cara R CR Cooper Margaret E ME Dagle John M JM Merrill David C DC Christensen Kaare K Simhan Hyagriv N HN Fong Chin-To CT Hallman Mikko M Muglia Louis J LJ Marazita Mary L ML Murray Jeffrey C JC
Pediatric research 20121120 2
<h4>Background</h4>The aim of this study was to identify genetic variants contributing to preterm birth (PTB) using a linkage candidate gene approach.<h4>Methods</h4>We studied 99 single-nucleotide polymorphisms (SNPs) for 33 genes in 257 families with PTBs segregating. Nonparametric and parametric analyses were used. Premature infants and mothers of premature infants were defined as affected cases in independent analyses.<h4>Results</h4>Analyses with the infant as the case identified two genes ...[more]
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