Ontology highlight
ABSTRACT:
SUBMITTER: Rothenberg ME
PROVIDER: S-EPMC3740732 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Rothenberg Marc E ME Spergel Jonathan M JM Sherrill Joseph D JD Annaiah Kiran K Martin Lisa J LJ Cianferoni Antonella A Gober Laura L Kim Cecilia C Glessner Joseph J Frackelton Edward E Thomas Kelly K Blanchard Carine C Liacouras Chris C Verma Ritu R Aceves Seema S Collins Margaret H MH Brown-Whitehorn Terri T Putnam Phil E PE Franciosi James P JP Chiavacci Rosetta M RM Grant Struan F A SF Abonia J Pablo JP Sleiman Patrick M A PM Hakonarson Hakon H
Nature genetics 20100307 4
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of eosinophils in the esophagus. We report association of EoE with variants at chromosome 5q22 encompassing TSLP and WDR36 (rs3806932, combined P = 3.19 x 10(-9)). TSLP is overexpressed in esophageal biopsies from individuals with EoE compared with unaffected individuals, whereas WDR36 expression is unaltered between the two groups. These data implicate the 5q22 locus in the pathogenesis of EoE and identify ...[more]