Ontology highlight
ABSTRACT:
SUBMITTER: Jeon TI
PROVIDER: S-EPMC3740797 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Jeon Tae-Il TI Esquejo Ryan M RM Roqueta-Rivera Manuel M Phelan Peter E PE Moon Young-Ah YA Govindarajan Subramaniam S SS Esau Christine C CC Osborne Timothy F TF
Cell metabolism 20130701 1
Sterol regulatory element-binding proteins (SREBPs) have evolved as a focal point for linking lipid synthesis with other pathways that regulate cell growth and survival. Here, we have uncovered a polycistrionic microRNA (miRNA) locus that is activated directly by SREBP-2. Two of the encoded miRNAs, miR-182 and miR-96, negatively regulate the expression of Fbxw7 and Insig-2, respectively, and both are known to negatively affect nuclear SREBP accumulation. Direct manipulation of this miRNA pathway ...[more]