Ontology highlight
ABSTRACT:
SUBMITTER: Ohtsuka N
PROVIDER: S-EPMC3740952 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Ohtsuka Nobuhisa N Badurek Sylvia S Busslinger Meinrad M Benes Francine M FM Minichiello Liliana L Rudolph Uwe U
Genesis (New York, N.Y. : 2000) 20130225 4
Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development. In a genetic approach to study functions of Pax5 in GABAergic neurons, Pax5 was specifically deleted in GABAergic neurons from Pax5 floxed mice using a novel Gad1-Cre transgenic mouse line expressing Cre recombinase in Gad1-positive, that is, GABAer ...[more]