Ontology highlight
ABSTRACT:
SUBMITTER: Cuchillo-Ibanez I
PROVIDER: S-EPMC3741172 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Cuchillo-Ibáñez Inmaculada I Balmaceda Valeria V Botella-López Arancha A Rabano Alberto A Avila Jesus J Sáez-Valero Javier J
PloS one 20130812 8
Reelin is a signaling protein increasingly associated with the pathogenesis of Alzheimer's disease that relevantly modulates tau phosphorylation. We have previously demonstrated that β-amyloid peptide (Aβ) alters reelin expression. We have now attempted to determine whether abnormal reelin triggered by Aβ will result in signaling malfunction, contributing to the pathogenic process. Here, we show that reelin forms induced by β-amyloid are less capable of down-regulating tau phosphorylation via di ...[more]