Ontology highlight
ABSTRACT:
SUBMITTER: Das U
PROVIDER: S-EPMC3741682 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Das Utpal U Scott David A DA Ganguly Archan A Koo Edward H EH Tang Yong Y Roy Subhojit S
Neuron 20130801 3
The convergence of APP (substrate) and BACE-1 (enzyme) is a rate-limiting, obligatory event triggering the amyloidogenic pathway-a key step in Alzheimer's disease (AD) pathology. However, as both APP/BACE-1 are highly expressed in brain, mechanisms precluding their unabated convergence are unclear. Exploring dynamic localization of APP/BACE-1 in cultured hippocampal neurons, we found that after synthesis via the secretory pathway, dendritic APP/BACE-1-containing vesicles are largely segregated i ...[more]