Ontology highlight
ABSTRACT:
SUBMITTER: Webster Marketon JI
PROVIDER: S-EPMC3741917 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Webster Marketon Jeanette I JI Corry Jacqueline J
FEBS open bio 20130725
Respiratory syncytial virus (RSV)-induced bronchiolitis in infants, although inflammatory in nature, is not responsive to glucocorticoids. We have recently shown that RSV-infected lung epithelial cells have impaired glucocorticoid receptor (GR)-mediated transactivation. In this study, we show that the N-terminal region of GR is required for RSV repression of GR transactivation and that RSV infection of lung epithelial cells reduces ligand-dependent GR phosphorylation at serine 211 and serine 226 ...[more]