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IL-17 in the rheumatologist's line of sight.

ABSTRACT: Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development of autoimmune and inflammatory arthritis. Furthermore, biotherapies targeting directly or indirectly IL-17 in inflammatory rheumatisms will be developed.

SUBMITTER: Truchetet ME

PROVIDER: S-EPMC3741932 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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IL-17 in the rheumatologist's line of sight.

Truchetet Marie-Elise ME Mossalayi M Djavad MD Boniface Katia K

BioMed research international 20130725

Over the past decades, the identification of several new cytokines, including interleukin (IL)-17 and IL-23, and of new T helper cell subsets, including Th17 cells, has changed the vision of immunological processes. The IL-17/Th17 pathway plays a critical role during the development of inflammation and autoimmunity, and targeting this pathway has become an attractive strategy for a number of diseases. This review aims to describe the effects of IL-17 in the joint and its roles in the development ...[more]

PMID: 23984335

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