Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee S
PROVIDER: S-EPMC3742096 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Mukherjee Sayak S Zhu Jing J Zikherman Julie J Parameswaran Ramya R Kadlecek Theresa A TA Wang Qi Q Au-Yeung Byron B Ploegh Hidde H Kuriyan John J Das Jayajit J Weiss Arthur A
Science signaling 20130101 256
The Src and Syk families of kinases are two distinct sets of kinases that play critical roles in initiating membrane-proximal B cell receptor (BCR) signaling. However, unlike in other lymphocytes, such as T cells, the "division of labor" between Src family kinases (SFKs) and Syk in B cells is not well separated because both Syk and SFKs can phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs) present in proteins comprising the BCR. To understand why B cells require both SFKs and ...[more]