Transduction of voltage and Ca2+ signals by Slo1 BK channels.
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ABSTRACT:
SUBMITTER: Hoshi T
PROVIDER: S-EPMC3742125 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Transduction of voltage and Ca2+ signals by Slo1 BK channels.
Hoshi T T Pantazis A A Olcese R R
Physiology (Bethesda, Md.) 20130501 3
Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism. ...[more]
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