Ontology highlight
ABSTRACT:
SUBMITTER: Moroni M
PROVIDER: S-EPMC3742235 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Moroni Maria M Maeda Daisuke D Whitnall Mark H MH Bonner William M WM Redon Christophe E CE
International journal of molecular sciences 20130708 7
There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for such a model is the minipig. Here, we evaluate the minipig for its potential in γ-H2AX-based biodosimetry after exposure to ionizing radiation using both Cs137 and Co60 sources. γ-H2AX foci were enumerated in blood lymphocytes and normal fibroblasts of human and porcine origin after ex vivo γ-ray irradiation. DNA double-strand break repair k ...[more]