Ontology highlight
ABSTRACT:
SUBMITTER: Morita S
PROVIDER: S-EPMC3742264 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Morita Sumiyo S Horii Takuro T Kimura Mika M Ochiya Takahiro T Tajima Shoji S Hatada Izuho I
International journal of molecular sciences 20130712 7
Members of the microRNA-29 (miR-29) family directly target the DNA methyltransferases, DNMT3A and DNMT3B. Disturbances in the expression levels of miR-29 have been linked to tumorigenesis and tumor aggressiveness. Members of the miR-29 family are currently thought to repress DNA methylation and suppress tumorigenesis by protecting against de novo methylation. Here, we report that members of the miR-29 family repress the activities of DNA methyltransferases and DNA demethylases, which have opposi ...[more]