Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.
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ABSTRACT:
SUBMITTER: Paffenholz R
PROVIDER: S-EPMC374230 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
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Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.
Paffenholz Rainer R Bergstrom Rebecca A RA Pasutto Francesca F Wabnitz Philipp P Munroe Robert J RJ Jagla Wolfgang W Heinzmann Ulrich U Marquardt Andreas A Bareiss Armin A Laufs Jürgen J Russ Andreas A Stumm Gabriele G Schimenti John C JC Bergstrom David E DE
Genes & development 20040310 5
The vestibular system of the inner ear is responsible for the perception of motion and gravity. Key elements of this organ are otoconia, tiny biomineral particles in the utricle and the saccule. In response to gravity or linear acceleration, otoconia deflect the stereocilia of the hair cells, thus transducing kinetic movements into sensorineural action potentials. Here, we present an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase ...[more]
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