Ontology highlight
ABSTRACT:
SUBMITTER: Hughes T
PROVIDER: S-EPMC3742307 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Hughes Tiffany T Becknell Brian B Freud Aharon G AG McClory Susan S Briercheck Edward E Yu Jianhua J Mao Charlene C Giovenzana Chiara C Nuovo Gerard G Wei Lai L Zhang Xiaoli X Gavrilin Mikhail A MA Wewers Mark D MD Caligiuri Michael A MA
Immunity 20100601 6
Among human natural killer (NK) cell intermediates in secondary lymphoid tissue (SLT), stage 3 CD34(-)CD117(+)CD161(+)CD94(-) immature NK (iNK) cells uniquely express aryl hydrocarbon receptor (AHR) and interleukin-22 (IL-22), supporting a role in mucosal immunity. The mechanisms controlling proliferation and differentiation of these cells are unknown. Here we demonstrate that the IL-1 receptor IL-1R1 was selectively expressed by a subpopulation of iNK cells that localized proximal to IL-1beta-p ...[more]