Ontology highlight
ABSTRACT:
SUBMITTER: Klemm RW
PROVIDER: S-EPMC3742324 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Klemm Robin W RW Norton Justin P JP Cole Ronald A RA Li Chen S CS Park Seong H SH Crane Matthew M MM Li Liying L Jin Diana D Boye-Doe Alexandra A Liu Tina Y TY Shibata Yoko Y Lu Hang H Rapoport Tom A TA Farese Robert V RV Blackstone Craig C Guo Yi Y Mak Ho Yi HY
Cell reports 20130516 5
Lipid droplets (LDs) are the major fat storage organelles in eukaryotic cells, but how their size is regulated is unknown. Using genetic screens in C. elegans for LD morphology defects in intestinal cells, we found that mutations in atlastin, a GTPase required for homotypic fusion of endoplasmic reticulum (ER) membranes, cause not only ER morphology defects, but also a reduction in LD size. Similar results were obtained after depletion of atlastin or expression of a dominant-negative mutant, whe ...[more]