Ontology highlight
ABSTRACT:
SUBMITTER: Sultana R
PROVIDER: S-EPMC3742328 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Sultana Rebeka R McNeill Daniel R DR Abbotts Rachel R Mohammed Mohammed Z MZ Zdzienicka Malgorzata Z MZ Qutob Haitham H Seedhouse Claire C Laughton Charles A CA Fischer Peter M PM Patel Poulam M PM Wilson David M DM Madhusudan Srinivasan S
International journal of cancer 20120328 10
An apurinic/apyrimidinic (AP) site is an obligatory cytotoxic intermediate in DNA Base Excision Repair (BER) that is processed by human AP endonuclease 1 (APE1). APE1 is essential for BER and an emerging drug target in cancer. We have isolated novel small molecule inhibitors of APE1. In this study, we have investigated the ability of APE1 inhibitors to induce synthetic lethality (SL) in a panel of DNA double-strand break (DSB) repair deficient and proficient cells; i) Chinese hamster (CH) cells: ...[more]