Ontology highlight
ABSTRACT:
SUBMITTER: Cerdeira AS
PROVIDER: S-EPMC3742368 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cerdeira Ana Sofia AS Rajakumar Augustine A Royle Caroline M CM Lo Agnes A Husain Zaheed Z Thadhani Ravi I RI Sukhatme Vikas P VP Karumanchi S Ananth SA Kopcow Hernan D HD
Journal of immunology (Baltimore, Md. : 1950) 20130313 8
NK cells that populate the decidua are important regulators of normal placentation. In contrast to peripheral blood NK cells, decidual NK (dNK) cells lack cytotoxicity, secrete proangiogenic factors, and regulate trophoblast invasion. In this study we show that exposure to a combination of hypoxia, TGF-β1, and a demethylating agent results in NK cells that express killer cell Ig-like receptors, the dNK cell markers CD9 and CD49a, and a dNK pattern of chemokine receptors. These cells secrete vasc ...[more]