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Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.

ABSTRACT: Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumbens core (NAcore), measured as an increase in dendritic spine diameter. These results show that rapid context-evoked synaptic potentiation in the NAcore may underpin relapse to cocaine use.

SUBMITTER: Stankeviciute NM

PROVIDER: S-EPMC3742620 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.

Stankeviciute Neringa M NM Scofield Michael D MD Kalivas Peter W PW Gipson Cassandra D CD

Addiction biology 20130506 6

Addiction to cocaine produces long-lasting, stable changes in brain synaptic physiology that might contribute to the vulnerability to relapse. In humans, exposure to environmental contexts previously paired with drug use precipitates relapse, but the neurobiological mechanisms mediating this process are unknown. Initiation of cocaine relapse via re-exposure to a drug-associated context elicited reinstatement of cocaine seeking as well as rapid, transient synaptic plasticity in the nucleus accumb ...[more]

PMID: 23648005

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