Ontology highlight
ABSTRACT:
SUBMITTER: Sterling NW
PROVIDER: S-EPMC3742686 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Neurobiology of aging 20130629 11
Parkinson's disease (PD) is marked pathologically by nigrostriatal dopaminergic terminal loss. Histopathological and in vivo labeling studies demonstrate that this loss occurs most extensively in the caudal putamen and caudate head. Previous structural studies have suggested reduced striatal volume and atrophy of the caudate head in PD subjects. The spatial distribution of atrophy in the putamen, however, has not been characterized. We aimed to delineate the specific locations of atrophy in both ...[more]