Ontology highlight
ABSTRACT:
SUBMITTER: Tarpey PS
PROVIDER: S-EPMC3743157 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Tarpey Patrick S PS Behjati Sam S Cooke Susanna L SL Van Loo Peter P Wedge David C DC Pillay Nischalan N Marshall John J O'Meara Sarah S Davies Helen H Nik-Zainal Serena S Beare David D Butler Adam A Gamble John J Hardy Claire C Hinton Jonathon J Jia Ming Ming MM Jayakumar Alagu A Jones David D Latimer Calli C Maddison Mark M Martin Sancha S McLaren Stuart S Menzies Andrew A Mudie Laura L Raine Keiran K Teague Jon W JW Tubio Jose M C JM Halai Dina D Tirabosco Roberto R Amary Fernanda F Campbell Peter J PJ Stratton Michael R MR Flanagan Adrienne M AM Futreal P Andrew PA
Nature genetics 20130616 8
Chondrosarcoma is a heterogeneous collection of malignant bone tumors and is the second most common primary malignancy of bone after osteosarcoma. Recent work has identified frequent, recurrent mutations in IDH1 or IDH2 in nearly half of central chondrosarcomas. However, there has been little systematic genomic analysis of this tumor type, and, thus, the contribution of other genes is unclear. Here we report comprehensive genomic analyses of 49 individuals with chondrosarcoma (cases). We identif ...[more]